The Biological Role of Stochasticity from Molecules to Communities

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dc.contributor.advisorRanganathan, Ramaen
dc.contributor.committeeMemberSüel, Gürol M.en
dc.contributor.committeeMemberAlto, Nealen
dc.contributor.committeeMemberRizo-Rey, Joséen
dc.creatorKittisopikul, Mark Andrewen
dc.date.accessioned2017-06-14T19:31:16Z
dc.date.available2017-06-14T19:31:16Z
dc.date.created2014-05
dc.date.issued2013-07-17
dc.date.submittedMay 2014
dc.date.updated2017-06-14T19:30:16Z
dc.description.abstractThe presence of stochasticity in biology engenders the question of the role of such randomness. While stochasticity may be an artifact of biochemical interactions, it could also be an actively regulated aspect of life. Here I investigate how noise may be encoded within the molecular interactions of a biochemical network and then examine how those consequences propagate to higher levels of organization including isogenic populations of cells and host-pathogen interactions. I particularly look into how this variability impacts the ability of populations to respond to their environments. I conclude that stochasticity is selectable property of life that adds robustness to biological processes during periods of uncertainty.en
dc.format.mimetypeapplication/pdfen
dc.identifier.oclc990065818
dc.identifier.urihttps://hdl.handle.net/2152.5/4143
dc.language.isoenen
dc.subjectCell Cycleen
dc.subjectHost-Pathogen Interactionsen
dc.subjectModels, Biologicalen
dc.subjectStochastic Processesen
dc.subjectSystems Biologyen
dc.titleThe Biological Role of Stochasticity from Molecules to Communitiesen
dc.typeThesisen
dc.type.materialtexten
thesis.degree.departmentGraduate School of Biomedical Sciencesen
thesis.degree.disciplineMolecular Biophysicsen
thesis.degree.grantorUT Southwestern Medical Centeren
thesis.degree.levelDoctoralen
thesis.degree.nameDoctor of Philosophyen

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