FOXO is the Mediator Linking Temporal Differentiation and the Insulin Signaling Pathway

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dc.contributor.advisorCameron, Scotten
dc.creatorLah, Carol Joonhyunen
dc.date.accessioned2010-07-12T18:00:58Z
dc.date.available2010-07-12T18:00:58Z
dc.date.issued2005-12-20
dc.description.abstractThe timing of differentiation is crucial for the correct development of an organism, because specific pathways can be used reiteratively to differentiate cells. Until recently, the molecular mechanism behind the temporal control of differentiation has remained elusive. Bateman and McNeill (2004) revealed a novel role for the insulin/insulin-like growth factor receptor (InR) pathway in regulating the timing of differentiation in neuronal photoreceptor cells in the Drosophila compound eye. The link between the InR pathway and temporal differentiation is significant, because of the implication that external factors, e.g. nutrition, are tightly coupled to the timing of differentiation. This proposal tests the hypothesis that FOXO, a crucial component of the InR pathway, mediates the regulation of developmental timing. The aims are the following: 1. Observe if dFOXO mutants affect temporal differentiation in the Drosophila eye. 2. Perform epistasis experiments to determine if dFOXO is downstream of other insulin signaling components. 3. Analyze the downstream targets of dFOXO that may play a role in neuronal differentiation.en
dc.format.digitalOriginborn digitalen
dc.format.mediumElectronicen
dc.format.mimetypeapplication/pdfen
dc.identifier.oclc62783759
dc.identifier.urihttps://hdl.handle.net/2152.5/421
dc.language.isoenen
dc.subjectSignal Transductionen
dc.subjectInsulinen
dc.subjectCell Differentiationen
dc.subjectForkhead Transcription Factorsen
dc.titleFOXO is the Mediator Linking Temporal Differentiation and the Insulin Signaling Pathwayen
dc.typeThesisen
dc.type.genredissertationen
dc.type.materialTexten
thesis.date.available2005-12-20
thesis.degree.departmentGraduate School of Biomedical Sciencesen
thesis.degree.disciplineGenetics and Developmenten
thesis.degree.grantorUT Southwestern Medical Centeren
thesis.degree.levelMastersen
thesis.degree.nameMaster of Scienceen

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