Cell Migration and Survival Pathways in Cardiac Development and Disease

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dc.contributor.advisorSrivastava, Deepaken
dc.creatorSaxena, Ankuren
dc.date.accessioned2010-07-12T18:09:38Z
dc.date.available2010-07-12T18:09:38Z
dc.date.issued2005-12-20
dc.descriptionThe file named "saxenaankur.pdf" is the primary dissertation file. All other files ("*.asf", "*.avi") are supplemental files and may be viewed individually.en
dc.description.abstractMammalian cardiac development is a complex process, rendering it susceptible to errors. As a result, congenital heart defects are the most common type of birth defect. Furthermore, heart disease in adults is the leading cause of mortality in the developed world. Given these statistics, gaining an understanding of cardiac development and disease is of paramount importance. Here, data are presented suggesting that the signaling molecules SDF-1, ephrin-B1, and ephrin-B2 play important roles in proper valve formation and maturation during cardiogenesis. Furthermore, another signaling molecule, thymosin ᴬ is implicated in promoting cell survival, potentially through an ILK-Akt pathway, as well as angiogenesis in the treatment of mice post-myocardial infarction. Finally, SDF-1 not only plays a role in cardiac development but, in a manner strikingly similar to the actions of thymosin ᴬ also appears to have therapeutic benefit post-myocardial infarction through the ILK-Akt pathway, reduced cell death, and increased angiogenesis. Together, these data and other information presented herein suggest new roles for signaling molecules in both cardiogenesis and cardiac therapy.en
dc.format.digitalOriginborn digitalen
dc.format.mediumElectronicen
dc.format.mimetypeapplication/pdfen
dc.identifier.oclc63167464
dc.identifier.urihttps://hdl.handle.net/2152.5/467
dc.language.isoenen
dc.subjectChemokines, CXCen
dc.subjectIntercellular Signaling Peptides and Proteinsen
dc.subjectHeart Defects, Congenitalen
dc.titleCell Migration and Survival Pathways in Cardiac Development and Diseaseen
dc.typeThesisen
dc.type.genredissertationen
dc.type.materialTexten
thesis.date.available2006-12-20
thesis.degree.departmentGraduate School of Biomedical Sciencesen
thesis.degree.disciplineGenetics and Developmenten
thesis.degree.grantorUT Southwestern Medical Centeren
thesis.degree.levelDoctoralen
thesis.degree.nameDoctor of Philosophyen

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UT Southwestern Graduate School of Biomedical Sciences