HDL Phospholipid and ABCA1-Mediated Cholesterol Efflux Are Reduced in Patients with Very High HDL-C Who Develop Early Coronary Artery Disease
| dc.contributor.committeeMember | Khera, Amit | en |
| dc.contributor.committeeMember | Hobbs, Helen H. | en |
| dc.contributor.committeeMember | Grundy, Scott M. | en |
| dc.creator | Agarwala, Anandita | en |
| dc.date.accessioned | 2016-06-27T19:56:01Z | |
| dc.date.available | 2016-06-27T19:56:01Z | |
| dc.date.created | 2014-05 | |
| dc.date.issued | 2014-04-15 | |
| dc.date.submitted | May 2014 | |
| dc.date.updated | 2016-06-27T19:48:21Z | |
| dc.description.abstract | BACKGROUND: Plasma levels of high-density lipoprotein cholesterol (HDL-C) are strongly inversely associated with coronary artery disease (CAD), and high HDL-C is generally associated with apparent ‘protection’ from CAD. OBJECTIVE: We identified a number of individuals with high HDL-C levels who develop CAD, a paradoxical phenotype and hypothesized that such individuals may have HDL with altered structure and function, and compared controls with similarly high HDL-C and no coronary disease. METHODS: 55 subjects with HDL-C above the 90th percentile, early CAD, and no major known risk factors for coronary disease were identified. We selected 120 controls without CAD, each matched for race, gender, and HDL-C level. RESULTS: Comparison of HDL particle characteristics between cases and controls demonstrated a significant reduction in HDL phospholipid composition and cholesterol efflux capacity in cases as compared to controls. CONCLUSION: Reduced cholesterol efflux capacity in cases with elevated HDL-C and CAD may explain the development of early coronary artery disease. Cholesterol efflux capacity may in fact be a better predictor of the risk of coronary disease then HDL-C levels alone. The reduction in HDL phospholipid in the cases may help account for impaired cholesterol efflux. | en |
| dc.format.mimetype | application/pdf | en |
| dc.identifier.oclc | 952355490 | |
| dc.identifier.uri | https://hdl.handle.net/2152.5/3299 | |
| dc.language.iso | en_US | en |
| dc.subject | Cholesterol | en |
| dc.subject | Coronary Artery Disease | en |
| dc.subject | Lipoproteins, HDL | en |
| dc.title | HDL Phospholipid and ABCA1-Mediated Cholesterol Efflux Are Reduced in Patients with Very High HDL-C Who Develop Early Coronary Artery Disease | en |
| dc.type | Thesis | en |
| dc.type.material | text | en |
| thesis.degree.department | UT Southwestern Medical School | en |
| thesis.degree.discipline | Research | en |
| thesis.degree.grantor | UT Southwestern Medical Center | en |
| thesis.degree.level | Doctoral | en |
| thesis.degree.name | M.D. with Distinction | en |