Spontaneous Neurotransmission as a Driver of Calcium Signaling

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dc.contributor.advisorKim, Tae-Kyungen
dc.contributor.committeeMemberKavalali, Ege T.en
dc.contributor.committeeMemberMonteggia, Lisaen
dc.contributor.committeeMemberBezprozvanny, Ilyaen
dc.creatorReese, Austin Lowellen
dc.date.accessioned2019-01-03T21:11:33Z
dc.date.available2019-01-03T21:11:33Z
dc.date.created2016-12
dc.date.issued2016-09-20
dc.date.submittedDecember 2016
dc.date.updated2019-01-03T21:11:33Z
dc.description.abstractSpontaneous neurotransmission is a stochastic mode of neurotransmitter release that is not coupled to action potential arrival at the presynapse. Recent evidence has shed light upon the presynaptic and vesicular fusion machinery that makes this mode of release unique to action potential driven, or evoked release, yet the postsynaptic reception of these differing signals has yet to be probed in detail. Here, I illustrate that evoked and spontaneous release modes coexist within the same synapses, yet the neurotransmitter released falls upon separate subsets of postsynaptic receptors. As a consequence of this phenomenon, in glutamatergic hippocampal synapses the NMDA receptors activated by spontaneous release are able to drive large calcium transients that maintain synaptic homeostasis and suppress local protein synthesis.en
dc.format.mimetypeapplication/pdfen
dc.identifier.oclc1080644326
dc.identifier.urihttps://hdl.handle.net/2152.5/6148
dc.language.isoenen
dc.subjectCalciumen
dc.subjectReceptors, N-Methyl-D-Aspartateen
dc.subjectSynapsesen
dc.subjectSynaptic Transmissionen
dc.titleSpontaneous Neurotransmission as a Driver of Calcium Signalingen
dc.typeThesisen
dc.type.materialtexten
thesis.degree.departmentGraduate School of Biomedical Sciencesen
thesis.degree.disciplineNeuroscienceen
thesis.degree.grantorUT Southwestern Medical Centeren
thesis.degree.levelDoctoralen
thesis.degree.nameDoctor of Philosophyen

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