Sex differences in severity of metabolic complications in patients with congenital generalized lipodystrophy




Lima, Josivan Gomes
Nobrega, Lucia Helena Coelho
Baracho, Maria de Fatima Paiva
Lima, Lucas Nobrega
de Melo Campos, Julliane Tamara Araújo
Lima, Debora Nobrega
Lima, Grayce Ellen Paiva
Fernandes, Virginia Oliveira
Montenegro Júnior, Renan Magalhães
Garg, Abhimanyu

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CONTEXT: Previous data support a higher prevalence of metabolic complications in females affected with familial partial lipodystrophy than in males. However, whether there are any sex differences in the prevalence and severity of metabolic complications among patients with congenital generalized lipodystrophy (CGL) remains unclear. OBJECTIVES: To compare prevalence of metabolic complications and metabolic parameters between males and females with CGL. DESIGN: A retrospective, cross-sectional comparison. SETTINGS: Patients from two tertiary referral centers from Northeastern Brazil - Universidade Federal do Rio Grande do Norte, Natal, and Universidade Federal do Ceará, Fortaleza. PATIENTS: A total of 44 females (age 2-51 years) and 28 males (age 5-46 years) with CGL. Twenty-six (7 M, 19 F) had genotypically confirmed CGL type 1, 43 (20 M, 23 F) had CGL type 2, and 3 patients were not genotyped. MAIN OUTCOME MEASURES: Prevalence of diabetes mellitus and hypertriglyceridemia, and metabolic variables. RESULTS: Females with CGL, as compared to males, had significantly increased prevalence of diabetes (82% vs. 54%; p<0.01) and hypertriglyceridemia (91% vs. 71%; p=0.05); and had higher median fasting serum triglycerides levels (383 vs. 221 mg/dL; p=0.01), but not statistically significantly higher median hemoglobin A1c (7.9% vs. 6.5%; p=0.37) and fasting serum glucose levels (138 vs. 89 mg/dL; p=0.06). CONCLUSIONS: Compared to males, females with CGL have increased prevalence of metabolic complications, such as diabetes and hypertriglyceridemia, suggesting need for close monitoring of metabolic parameters, and early and aggressive intervention among them.

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The attached file includes supplementary tables. This submission meets the Extended Data Sets and Supplemental Materials requirements that are included in author guidelines for the Journal of Clinical Endocrinology & Metabolism (Print ISSN 0021-972X, Online ISSN 1945-7197).

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Lima JG, Nobrega LHC, Baracho M de FP, Lima LN, de Melo Campos JTA, Lima DN, Lima GEP, Fernandes VO, Montenegro Júnior RM, Garg A. Data from: Sex differences in severity of metabolic complications in patients with congenital generalized lipodystrophy. UT Southwestern Institutional Repository 2022. Deposited 15 December 2022.

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