An Atypical Minimal Kinase Inactivates the Molecular Chaperone Hsp90

dc.contributor.advisorLehrman, Mark A.en
dc.contributor.committeeMemberGoodman, Joel M.en
dc.contributor.committeeMemberZhang, Xuewuen
dc.contributor.committeeMemberTagliabracci, Vincent S.en
dc.creatorPark, Brenden Chulen
dc.creator.orcid0000-0003-4052-2930
dc.date.accessioned2024-01-11T20:19:18Z
dc.date.available2024-01-11T20:19:18Z
dc.date.created2021-12
dc.date.issuedDecember 2021
dc.date.submittedDecember 2021
dc.date.updated2024-01-11T20:19:18Z
dc.description.abstractBacteria utilize a wide variety of proteins, termed effectors, to achieve virulence. We have identified an atypical kinase, HopBF1, found primarily in the plant pathogen Pseudomonas syringae. HopBF1 specifically inactivates Hsp90 causing the degradation of numerous Hsp90 clients, ultimately culminating in cell death and tissue necrosis. We further propose a remarkable betrayal mechanism in which HopBF1 masquerades as a host Hsp90 client to achieve specificity, followed by inactivation of the molecular chaperone.en
dc.format.mimetypeapplication/pdfen
dc.identifier.oclc1417098227
dc.identifier.urihttps://hdl.handle.net/2152.5/10224
dc.language.isoenen
dc.subjectArabidopsis Proteinsen
dc.subjectBacterial Proteinsen
dc.subjectHSP90 Heat-Shock Proteinsen
dc.subjectMolecular Mimicryen
dc.subjectPlant Immunityen
dc.titleAn Atypical Minimal Kinase Inactivates the Molecular Chaperone Hsp90en
dc.typeThesisen
dc.type.materialtexten
thesis.degree.departmentGraduate School of Biomedical Sciencesen
thesis.degree.disciplineCell and Molecular Biologyen
thesis.degree.grantorUT Southwestern Medical Centeren
thesis.degree.levelDoctoralen
thesis.degree.nameDoctor of Philosophyen

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