Role of Mash1-E Protein Heterodimers in Mash1 Function in the Developing Neural Tube

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dc.contributor.advisorLu, Q. Richarden
dc.creatorCollisson, Tandi Louiseen
dc.date.accessioned2010-07-12T19:00:19Z
dc.date.available2010-07-12T19:00:19Z
dc.date.issued2003-05-01
dc.description.abstractNeural-specific Class II bHLH transcription factors heterodimerize with ubiquitous Class I bHLH E proteins to form complexes required for neural differentiation. There are four known E proteins, HEB, E12, E47 and E2.2, in the mammalian nervous system, which potentially form heterodimers with Mash1 in the neural tube. To test the relevance of particular Mash1-E protein heterodimer combinations in vivo, I constructed tethered Mash1-E protein heterodimers for over-expression in the chick neural tube. By comparing overexpression of Mash1 with over-expression of these Mash1-E protein heterodimers, their abilities to effect neural differentiation and cell-type specification were analyzed. Mash1-E protein heterodimers are interchangeable in the function of driving neurogenesis in the chick neural tube. The effects of Mash1-E protein heterodimers on cell-type specificity were different, suggesting non-redundant functions in effecting dorsal interneuron populations. Furthermore, additional Mash1 heterodimer partners may be required for the cell-type specification function of Mash1.en
dc.format.digitalOriginborn digitalen
dc.format.mediumElectronicen
dc.format.mimetypeapplication/pdfen
dc.identifier.oclc59227025
dc.identifier.urihttps://hdl.handle.net/2152.5/762
dc.language.isoenen
dc.subjectNeurogenesisen
dc.subjectInterneuronsen
dc.subjectBasic Helix-Loop-Helix Transcription Factorsen
dc.titleRole of Mash1-E Protein Heterodimers in Mash1 Function in the Developing Neural Tubeen
dc.typeThesisen
dc.type.genredissertationen
dc.type.materialTexten
thesis.date.available2004-04-23
thesis.degree.departmentGraduate School of Biomedical Sciencesen
thesis.degree.disciplineNeuroscienceen
thesis.degree.grantorUT Southwestern Medical Centeren
thesis.degree.levelMastersen
thesis.degree.nameMaster of Scienceen

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