The Functional Roles of Steroidogenic Factor 1 in the Ventromedial Nucleus of the Hypothalamus

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dc.contributor.advisorParker, Keith L.en
dc.creatorKim, Ki Wooen
dc.date.accessioned2010-07-12T18:25:34Z
dc.date.available2010-07-12T18:25:34Z
dc.date.issued2009-06-17
dc.description.abstractSteroidogenic factor 1 (SF-1) is a nuclear receptor that plays important roles in the hypothalamic-pituitary-steroidogenic organ axis. Global knockout studies in mice revealed the essential in vivo roles of SF-1 in the ventromedial hypothalamic nucleus (VMH), adrenal glands, and gonads. One limitation of global SF-1 knockout mice is their early postnatal death from adrenocortical insufficiency. To overcome limitations of the global knockout mice and to delineate the roles of SF-1 in the brain, we used Cre/loxP recombination technology to genetically ablate SF-1 specifically in the central nervous system (CNS). Mice with CNS-specific knockout of SF-1 mediated by nestin-Cre showed increased anxiety-like behavior, revealing a crucial role of SF-1 in a complex behavioral phenotype. Our studies with CNS-specific SF-1 KO mice also defined roles of SF-1 in regulating the VMH expression of target genes implicated in anxiety and energy homeostasis. Therefore, present work will focus on the functional roles of SF-1 in the VMH linked to anxiety and energy homeostasis.en
dc.format.digitalOriginborn digitalen
dc.format.mediumElectronicen
dc.format.mimetypeapplication/pdfen
dc.identifier.oclc754616698
dc.identifier.urihttps://hdl.handle.net/2152.5/548
dc.language.isoenen
dc.subjectSteroidogenic Factor 1en
dc.subjectVentromedial Hypothalamic Nucleusen
dc.subjectGene Expression Regulationen
dc.titleThe Functional Roles of Steroidogenic Factor 1 in the Ventromedial Nucleus of the Hypothalamusen
dc.typeThesisen
dc.type.genredissertationen
dc.type.materialTexten
thesis.date.available2011-06-17
thesis.degree.departmentGraduate School of Biomedical Sciencesen
thesis.degree.disciplineNeuroscienceen
thesis.degree.grantorUT Southwestern Medical Centeren
thesis.degree.levelDoctoralen
thesis.degree.nameDoctor of Philosophyen

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