Regulation of Body Composition by the Microbiota and the Circadian Clock

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dc.contributor.advisorGreen, Carla B.en
dc.contributor.committeeMemberLiu, Yien
dc.contributor.committeeMemberWan, Yihongen
dc.contributor.committeeMemberHooper, Lora V.en
dc.creatorWang, Yuhaoen
dc.creator.orcid0000-0002-4539-3720
dc.date.accessioned2020-01-02T18:22:51Z
dc.date.available2020-01-02T18:22:51Z
dc.date.created2017-12
dc.date.issued2017-11-21
dc.date.submittedDecember 2017
dc.date.updated2020-01-02T18:22:51Z
dc.description.abstractThe intestinal microbiota has been identified as an environmental factor that markedly impacts energy storage and body fat accumulation, yet the underlying mechanisms remain unclear. In this dissertation, I show that the microbiota regulates body composition through the circadian transcription factor NFIL3 in intestinal epithelial cells. First, epithelial NFIL3 promotes lipid absorption and export in the intestine by regulating a circadian expression program of epithelial lipid metabolic genes. Second, Nfil3 transcription oscillates diurnally in intestinal epithelial cells and the amplitude of the circadian oscillation is controlled by the microbiota through group 3 innate lymphoid cells (ILC3), STAT3, and the epithelial cell circadian clock. These findings provide mechanistic insight into how the intestinal microbiota regulates body composition and establish NFIL3 as an essential molecular link among the microbiota, the circadian clock, and host metabolism.en
dc.format.mimetypeapplication/pdfen
dc.identifier.oclc1134689298
dc.identifier.urihttps://hdl.handle.net/2152.5/7743
dc.language.isoenen
dc.subjectBasic-Leucine Zipper Transcription Factorsen
dc.subjectBody Compositionen
dc.subjectCircadian Clocksen
dc.subjectGastrointestinal Microbiomeen
dc.subjectIntestinesen
dc.titleRegulation of Body Composition by the Microbiota and the Circadian Clocken
dc.typeThesisen
dc.type.materialtexten
thesis.degree.departmentGraduate School of Biomedical Sciencesen
thesis.degree.disciplineIntegrative Biologyen
thesis.degree.grantorUT Southwestern Medical Centeren
thesis.degree.levelDoctoralen
thesis.degree.nameDoctor of Philosophyen

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