Identification of Scavenger Receptor B1 as the Airway Microfold Receptor for Mycobacterium tuberculosis

Date

2020-12-01T06:00:00.000Z

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Abstract

Mycobacterium tuberculosis (Mtb) can enter the body through multiple routes, including via specialized transcytotic cells called microfold cells (M cell). However, the mechanistic basis for M cell entry remains undefined. Here, I show that M cell transcytosis depdends on the Mtb Type VII secretion machine and its major virulence factor EsxA. I identify scavenger receptor B1 (SR-B1) as an EsxA receptor on airway M cells. SR-B1 is required for Mtb binding to and translocation across M cells in mouse and human tissue. Together, my data demonstrate a previously undescribed role for Mtb EsxA in mucosal invasion and identify SR-B1 as the airway M cell receptor for Mtb.

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Mycobacterium tuberculosis, Scavenger Receptors, Class B

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