The AfCS seeks a comprehensive understanding of cellular signaling networks, in all their spatial and temporal complexity. Embarking on this journey will be facilitated by assembling maps that can guide our research and trace our progress. Mapping networks that include thousands of molecules will require many years of exploration. To begin, we have assembled several crude maps that highlight pathways of known importance in mouse macrophages, B lymphocytes, and cardiac myocytes. These reference maps were designed to provide simple guides to very small parts of the much more complex signaling network of a cell. The maps allow you to link to more extensive information found within our Molecule Pages. We recognize that each map is necessarily incomplete and at best an inaccurate representation of the signaling machinery that regulates a particular cell function. Pathways are context-dependent, changing and evolving across different species, cell types, and environmental conditions. Eventually, the AfCS will represent and model signaling networks in much more complex formats, designed for generating testable hypotheses. As we tackle the task of mapping the complex terrain of signaling networks, we hope the crude modules presented here will guide us - and our readers - to making more comprehensive and powerful tools for navigating regulatory networks. To this end, we solicit from readers any criticisms or suggestions they wish to offer. We are especially interested to identify overt mistakes and molecules omitted from these maps. Suggestions, comments, and criticisms should be sent to firstname.lastname@example.org.
Map Concepts: Gil Sambrano
Web Page Design: Lisa Wable