Identification of Scavenger Receptor B1 as the Airway Microfold Receptor for Mycobacterium tuberculosis

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dc.contributor.advisorHooper, Lora V.en
dc.contributor.committeeMemberSchmid, Sandraen
dc.contributor.committeeMemberKohler, Jennifer J.en
dc.contributor.committeeMemberFarrar, J. Daviden
dc.creatorKhan, Haaris Suwaiden
dc.creator.orcid0000-0002-5115-2456
dc.date.accessioned2023-01-02T21:44:47Z
dc.date.available2023-01-02T21:44:47Z
dc.date.created2020-12
dc.date.issued2020-12-01T06:00:00.000Z
dc.date.submittedDecember 2020
dc.date.updated2023-01-02T21:44:48Z
dc.description.abstractMycobacterium tuberculosis (Mtb) can enter the body through multiple routes, including via specialized transcytotic cells called microfold cells (M cell). However, the mechanistic basis for M cell entry remains undefined. Here, I show that M cell transcytosis depdends on the Mtb Type VII secretion machine and its major virulence factor EsxA. I identify scavenger receptor B1 (SR-B1) as an EsxA receptor on airway M cells. SR-B1 is required for Mtb binding to and translocation across M cells in mouse and human tissue. Together, my data demonstrate a previously undescribed role for Mtb EsxA in mucosal invasion and identify SR-B1 as the airway M cell receptor for Mtb.en
dc.format.mimetypeapplication/pdfen
dc.identifier.oclc1356910605
dc.identifier.urihttps://hdl.handle.net/2152.5/10012
dc.language.isoenen
dc.subjectMycobacterium tuberculosisen
dc.subjectScavenger Receptors, Class Ben
dc.titleIdentification of Scavenger Receptor B1 as the Airway Microfold Receptor for Mycobacterium tuberculosisen
dc.typeThesisen
dc.type.materialtexten
thesis.degree.departmentGraduate School of Biomedical Sciencesen
thesis.degree.disciplineImmunologyen
thesis.degree.grantorUT Southwestern Medical Centeren
thesis.degree.levelDoctoralen
thesis.degree.nameDoctor of Philosophyen

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